RESEARCH
Throughout my career my research has focused on endothelial cells in physiological and pathological conditions and the regulatory role of the Vascular Endothelial Growth factor (VEGF). Furthermore, I have also studied the interaction between the endothelium and the immune system focusing on the process of lymphocyte transmigration.
RESEARCH TOPICS
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SELECTED PUBLICATIONS
1) Dragoni S., Caridi B., Karatsai E., Burgoyne T., Sarker M.H., Turowski P. AMP-activated protein kinase is a key regulator of acute neurovascular permeability. J Cell Sci. 2021 Mar 12:jcs.253179; doi: 10.1242/jcs.253179.
2) Dragoni S., Papageorgiou A., Araiz C., Greenwood J., Turowski P. Endothelial protease activated receptor 1 (PAR1) signalling is required for lymphocyte transmigration across brain microvascular endothelial cells. Cells. 2020 Dec 21; 9(12): E2723. doi: 10.3390/cells9122723.
3) Dragoni S., Caridi B., Karatsai E., Sarker M.H. and Turowski P. AMP-activated protein kinase is a key regulator of retinal vascular permeability. Preprint. bioRxiv 802033; doi: https://doi.org/10.1101/802033.
4) Dragoni S., Turowski P. Polarised VEGFA Signalling at Vascular Blood Neural Barriers. Int J Mol Sci. 2018 May 5;19(5).
5) Dragoni S., Hudson N., McKenzie J.A., Kenny B., Gill Y., Blaber R., Adamson P., Greenwood J. and Turowski P. Endothelial MAPKs direct ICAM-1 signaling to divergent inflammatory functions. J Immunol. 2017 Apr 3.
6) Dragoni S., Reforgiato M., Zuccolo E., Poletto V., Lodola F., Ruffinatti F.A., Bonetti E., Guerra G., Barosi G., Rosti V., Moccia F. Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony forming cells. Exp Hematol. 2015 Sep 30.
7) Dragoni S., Turin I., Laforenza U., Potenza M.D., Bottino C., Glasnov T.N., Prestia M., Ferulli F., Saitta A., Mosca A., Guerra G., Rosti V., Luinetti O., Ganini C., Porta C., Pedrazzoli P., Tanzi F., Montagna D, Moccia F. Store-operated Ca2+ entry does not control proliferation in primary cultures of human metastatic renal cellular carcinoma. Biomed Res Int. 2014; 2014: 739494.
8) Dragoni S., Guerra G., Pla A.F., Bertoni G., Rappa A., Poletto V., Bottino C., Aronica A., Lodola F., Cinelli M.P., Laforenza U., Rosti V., Tanzi F., Munaron L., Moccia F. A functional transient receptor potential vanilloid 4 (TRPV4) channel is expressed in human endothelial progenitor cells. J Cell Physiol. 2015 Jan; 230(1): 95-104.
9) Dragoni S., Laforenza U., Bonetti E., Reforgiato M., Poletto V., Lodola F., Bottino C., Guido D., Rappa A., Pareek S., Tomasello M., Guarrera M.R., Cinelli M.P., Aronica A., Guerra G., Barosi G., Tanzi F., Rosti V., Moccia F. Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis.PLoS One. 2014 Mar 6; 9(3): e91099.
10) Dragoni S., Bonetti E., Bottino C., Lodola F., Guerra G., Borghesi A., Stronati M., Laforenza U., Tanzi F., Rosti V. and Moccia F. Canonical transient receptor potential 3 (TRPC3) channel triggers VEGF-induced oscillation in intracellular Ca2+ concentration and proliferation in endothelial progenitor cells isolated from umbilical cord blood. Stem Cells Dev. 2013 Oct 1; 22(19): 2561-80.
11) Dragoni S., Laforenza U., Bonetti E., Lodola F., Bottino C., Bongio G.C., Berra Romani R., Guerra G., Pedrazzoli P., Rosti V., Tanzi F. and Moccia F. Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration. Stem Cells. 2011 Nov; 29(11): 1898-907.
12) Dragoni S., Bonetti E., Laforenza U., et al. VEGF induces human endothelial progenitor cells to proliferate by eliciting oscillations in intracellular Ca2+ concentration. Angiogenesis. 2011; 14: 94.